Extensions to amino acid description.
Mol Divers
; 14(4): 709-18, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-19937466
ABSTRACT
A new set of amino acid descriptor scales was recently introduced. The new scales relate to amino acid side chain (i) rigidity and (ii) flexibility. These two properties were found to be orthogonal to each other. In this study, (i) the understanding of their meaning is improved, (ii) their utility further corroborated, and (iii) the scope of their applicability is broadened. Notably, the rigidity and flexibility scales are benchmarked against previous amino acid description precedence and found to contribute (1) new information, and (2) direct interpretation. The suggested description extensions were tested using empirical data from peptide description and in quantitative structure-activity relationships (QSAR).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Sequência de Aminoácidos
/
Relação Quantitativa Estrutura-Atividade
/
Aminoácidos
Tipo de estudo:
Evaluation_studies
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article