Bioinformatic approaches for the structure and function of membrane proteins.
BMB Rep
; 42(11): 697-704, 2009 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-19944009
ABSTRACT
Membrane proteins play important roles in the biology of the cell, including intercellular communication and molecular transport. Their well-established importance notwithstanding, the high-resolution structures of membrane proteins remain elusive due to difficulties in protein expression, purification and crystallization. Thus, accurate prediction of membrane protein topology can increase the understanding of membrane protein function. Here, we provide a brief review of the diverse computational methods for predicting membrane protein structure and function, including recent progress and essential bioinformatics tools. Our hope is that this review will be instructive to users studying membrane protein biology in their choice of appropriate bioinformatics methods.
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Base de dados:
MEDLINE
Assunto principal:
Biologia Computacional
/
Proteínas de Membrana
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article