The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
Bioorg Med Chem Lett
; 20(1): 157-60, 2010 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-19945875
ABSTRACT
A series of tetrahydro-beta-carbolines were identified by HTS as inhibitors of the kinesin Eg5. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of removing potential metabolic liabilities and improving cellular potency.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carbolinas
/
Cinesinas
/
Inibidores Enzimáticos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article