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Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates.
Shang, Wenchi; Davies, Todd A; Flamm, Robert K; Bush, Karen.
Afiliação
  • Shang W; Johnson & Johnson Pharmaceutical Research & Development LLC, 1000 Route 202 South, Raritan, NJ 08869, USA. wshang2@its.jnj.com
Antimicrob Agents Chemother ; 54(2): 956-9, 2010 Feb.
Article em En | MEDLINE | ID: mdl-19949055
Induction of mecA by ceftobiprole and oxacillin in 18 methicillin-resistant Staphylococcus aureus clinical isolates with various SCCmec cassettes was examined using reverse transcriptase PCR. The magnitude of mecA induction, 3- to 65-fold for ceftobiprole and 2- to 69-fold for oxacillin, did not correlate with ceftobiprole MICs (or=256 microg/ml. No correlation between magnitude of induction and SCCmec type was found.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxacilina / Proteínas de Bactérias / Cefalosporinas / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Idioma: En Ano de publicação: 2010 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxacilina / Proteínas de Bactérias / Cefalosporinas / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Idioma: En Ano de publicação: 2010 Tipo de documento: Article