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Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals.
Brandes, M E; Allen, J B; Ogawa, Y; Wahl, S M.
Afiliação
  • Brandes ME; Cellular Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892.
J Clin Invest ; 87(3): 1108-13, 1991 Mar.
Article em En | MEDLINE | ID: mdl-1999490
Systemic administration of the cytokine, TGF beta 1, profoundly antagonized the development of polyarthritis in susceptible rats. TGF beta 1 administration (1 or 5 micrograms/animal), initiated one day before an arthritogenic dose of streptococcal cell wall (SCW) fragments, virtually eliminated the joint swelling and distortion typically observed during both the acute phase (articular index, AI = 2.5 vs. 11; P less than 0.025) and the chronic phase (AI = 0 vs. 12.5) of the disease. Moreover, TGF beta 1 suppressed the evolution of arthritis even when administration was begun after the acute phase of the disease. Histopathological examination of the joint revealed the systemic TGF beta 1 treatment greatly reduced inflammatory cell infiltration, pannus formation, and joint erosion. Consistent with the inhibition of inflammatory cell recruitment into the synovium, TGF beta 1 reversed the leukocytosis associated with the chronic phase of the arthritis. Control animals subjected to the same TGF beta 1 dosing regimen displayed no discernable immunosuppressive or toxic effects even after 4 wk of treatment. These observations not only provide insight into the immunoregulatory effects of TGF beta, but also implicate this cytokine as a potentially important therapeutic agent.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite / Fator de Crescimento Transformador beta Limite: Animals Idioma: En Ano de publicação: 1991 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite / Fator de Crescimento Transformador beta Limite: Animals Idioma: En Ano de publicação: 1991 Tipo de documento: Article