Circulating free nitrotyrosine and cognitive decline.
Acta Neurol Scand
; 122(3): 175-81, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20003087
ABSTRACT
OBJECTIVE:
To determine if the circulating nitrotyrosine level significantly correlates with parameters measuring cognitive abilities. MATERIALS ANDMETHODS:
One-hundred and twelve community-living subjects (ranging in age from 27 to 98 years) were evaluated for cognitive abilities [Mini Mental State Examination (MMSE) score] and circulating free nitrotyrosine plasma level, as well as for several variables that might influence cognitive abilities (age, education) and nitrotyrosine level (body mass index, haematological parameters, cardiovascular and inflammatory indices).RESULTS:
In the sub-group of cognitively impaired subjects (score at MMSE < 23.9), but not in that of cognitively not impaired subjects, a significant inverse correlation exists between nitrotyrosine level and MMSE score (r = -0.378; P < 0.02).CONCLUSIONS:
The finding, if confirmed by longitudinal studies, could play a role in the management of the subjects with Mild Cognitive Impairment, the clinical condition considered as a transitional state between the changes of cognitive ability in normal aging and dementia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tirosina
/
Transtornos Cognitivos
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article