Blood culture contamination rates after skin antisepsis with chlorhexidine gluconate versus povidone-iodine in a pediatric emergency department.
Infect Control Hosp Epidemiol
; 31(2): 171-6, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-20025532
ABSTRACT
OBJECTIVE:
To determine blood culture contamination rates after skin antisepsis with chlorhexidine, compared with povidone-iodine.DESIGN:
Retrospective, quasi-experimental study.SETTING:
Emergency department of a tertiary care children's hospital. PATIENTS Children aged 2-36 months with peripheral blood culture results from February 2004 to June 2008. Control patients were children younger than 2 months with peripheral blood culture results.METHODS:
Blood culture contamination rates were compared using segmented regression analysis of time-series data among 3 patient groups (1) patients aged 2-36 months during the 26-month preintervention period, in which 10% povidone-iodine was used for skin antisepsis before blood culture; (2) patients aged 2-36 months during the 26-month postintervention period, in which 3% chlorhexidine gluconate was used; and (3) patients younger than 2 months not exposed to the chlorhexidine intervention (ie, the control group).RESULTS:
Results from 11,595 eligible blood cultures were reviewed (4,942 from the preintervention group, 4,274 from the postintervention group, and 2,379 from the control group). For children aged 2-36 months, the blood culture contamination rate decreased from 24.81 to 17.19 contaminated cultures per 1,000 cultures (P < .05) after implementation of chlorhexidine. This decrease of 7.62 contaminated cultures per 1,000 cultures (95% confidence interval, -0.781 to -15.16) represented a 30% relative decrease from the preintervention period and was sustained over the entire postintervention period. No change in contamination rate was observed in the control group (P = .337).CONCLUSION:
Skin antisepsis with chlorhexidine significantly reduces the blood culture contamination rate among young children, as compared with povidone-iodine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Povidona-Iodo
/
Pele
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Coleta de Amostras Sanguíneas
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Clorexidina
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Antissepsia
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Contaminação de Equipamentos
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article