[Extracorporeal photochemotherapy]. / La photochimiothérapie extracorporelle.
Transfus Clin Biol
; 17(1): 28-33, 2010 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-20042357
ABSTRACT
Photopheresis or extracorporeal photochemotherapy (ECP) is a cellular therapy which combines a leukapheresis followed by ex vivo treatment using psoralen and ultraviolet A irradiation before reinfusion into the patient. Its mechanisms of action remain unclear and selective photodestruction of leukocytes cannot explain the long-lasting immunomodulatory effects. Recent studies demonstrated that ECP down regulates the immune response and induces tolerance through the maturation of dendritic cells and the production of regulatory T cells. Based on these effects, ECP is mainly used for treatment of Sezary syndrome, graft-versus-host disease, organ graft rejection and autoimmune diseases. However, it is still not clear how ECP both activates tumor immunity against cutaneous T-cell lymphoma and induces tolerance in autoreactive disorders. In addition, the use of adjuvant therapies, the long-term effects and various treatment protocols remain to be investigated along with the specific indications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia de Imunossupressão
/
Fotoferese
Tipo de estudo:
Etiology_studies
/
Guideline
Limite:
Humans
Idioma:
Fr
Ano de publicação:
2010
Tipo de documento:
Article