Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis.
J Cyst Fibros
; 9(2): 110-6, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-20045384
ABSTRACT
BACKGROUND:
Filamentous fungi are frequently recovered from respiratory cultures of individuals with CF.METHODS:
A CF cohort database was utilized to determine filamentous fungal prevalence and risk factors.RESULTS:
The prevalence of filamentous fungal isolation increased from 2.0% in 1997 to 28.7% in 2007. The odds of isolating filamentous fungi during a quarter was greater in CF adults [p<0.001], during chronic oral antibiotic use [p=0.002] and increased with each 10% drop in FEV(1) percent predicted [p=0.005], while inhaled corticosteroids surprisingly decreased the likelihood [p=0.012]. The direction of these effects persisted after excluding individuals with ABPA. A sub-analysis determined older age [p=0.019] and use of inhaled antibiotics [p=0.011] were independent risk factors for onset of fungal colonization.CONCLUSIONS:
This study suggests that isolation of filamentous fungi in CF at JHH has increased and risk factors include older age, decreased lung function, and chronic oral antibiotics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrose Cística
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Fungos
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Micoses
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Child
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Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article