2,4,6-trisubstituted triazines as protein a mimetics for the treatment of autoimmune diseases.
J Med Chem
; 53(3): 1138-45, 2010 Feb 11.
Article
em En
| MEDLINE
| ID: mdl-20047277
ABSTRACT
A first-in-class series of low molecular weight trisubstituted triazines were synthesized and evaluated for their ability to mimic protein A binding to human IgG antibody. The structure-activity relationship (SAR) demonstrates that the 1,3-phenylenediamine component was essential for robust activity. Twenty-two compounds, represented by lead molecule 34, displayed significant activity compared to protein A. These compounds may prove useful for the treatment of autoimmune disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína Estafilocócica A
/
Triazinas
/
Materiais Biomiméticos
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article