Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration.
J Clin Invest
; 120(1): 20-8, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-20051633
ABSTRACT
The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative medicine. From studies using model organisms, new insights into the fundamental pathways that drive heart muscle regeneration have begun to arise as well as a growing knowledge of the distinct families of multipotent cardiovascular progenitors that generate diverse lineages during heart development. In this Review, we highlight this intersection of the "pregenerative" biology of heart progenitor cells and heart regeneration and discuss the longer term challenges and opportunities in moving toward a therapeutic goal of regenerative cardiovascular medicine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Células-Tronco
/
Coração
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article