[Advances in the study of affinity selection-ultrafiltration/HPLC-MS].
Yao Xue Xue Bao
; 44(10): 1084-8, 2009 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-20055128
ABSTRACT
Affinity selection-ultrafiltration/HPLC-MS is the combination of the ultrafiltration and HPLC-MS, mainly used for screening small active molecular substances from combinatorial libraries and natural product extracts, which can bind to solution-phase targets. Besides, it can be used in metabolic screening and characterization of ligand-receptor binding. It is a complement to the traditional methods of screening and identifying drugs. This review describes its principle and application in drug study.
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Base de dados:
MEDLINE
Assunto principal:
Espectrometria de Massas
/
Ultrafiltração
/
Avaliação Pré-Clínica de Medicamentos
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article