[Relationship between the level of MCP-1 expression in sera of RA patients and ILD].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 26(1): 59-60, 2010 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-20056091
ABSTRACT
AIM:
To investigate the function and clinical significance of monocyte chemoattractant protein-1 MCP-1 in the pathogenesis of rheumatoid arthritis(RA)and the relation ship between the expression of MCP-1 in serum and interstitial lung disease (ILD) secondary from RA.METHODS:
60 patients with RA were divided into two groups 30 cases with simple RA group and 30 cases with ILD secondary from RA (RA+ILD group). The control group incuided 20 healthy cases. Enzyme linked immunosorbent assay (ELISA ) was used to determine the serum expression of MCP-1 in patients healthy controls. The differences of MCP-1 level and other laboratory indexes (IgG, IgA, IgM, alpha2-G, gamma-G, RF, ESR, CRP, and the number of arthrocele) in different groups were compared with software spss13.0.RESULTS:
The expression of MCP-1 in simple RA patients was significantly higher than that in the control group (P>0.05) and significantly lower than that in the RA+ILD group (P>0.01). The level of MCP-1 in serum of RA patieuts was positively correlated with IgG, IgM, and gamma-G.CONCLUSION:
MCP-1 plays an important role in the pathogenesis of RA and may contribute to the promotion of lung fibrosis in ILD secondary from RA.
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Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Doenças Pulmonares Intersticiais
/
Quimiocina CCL2
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article