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The Epilepsy Genetic Association Database (epiGAD): analysis of 165 genetic association studies, 1996-2008.
Tan, Nigel C K; Berkovic, Samuel F.
Afiliação
  • Tan NC; Department of Neurology, National Neuroscience Institute, Singapore city, Singapore. nigel.tan@alumni.nus.edu.sg
Epilepsia ; 51(4): 686-9, 2010 Apr.
Article em En | MEDLINE | ID: mdl-20074235
We have created the Epilepsy Genetic Association Database (epiGAD, http://www.epigad.org, an online database of epilepsy genetic association studies. A systematic search using several search engines identified 165 studies. Herein we analyze the types of studies available, the sample sizes used, and the strength of the findings. Common questions examined were susceptibility to idiopathic generalized epilepsy, focal epilepsy, or febrile seizures, and pharmacogenomic approaches to drug-resistant epilepsy. Sample sizes were generally small; 80% of studies had 200 or fewer cases, although more recent studies published from 2005-2008 incorporated slightly larger sample sizes. No association was judged as "strong" using current criteria for assessing genetic associations--this is probably due to inadequate sample sizes. Sample sizes need to increase, either by research collaboration or via systematic reviews and meta-analyses. We believe epiGAD will facilitate future meta-analyses.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bases de Dados Genéticas / Epilepsia / Estudos de Associação Genética Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bases de Dados Genéticas / Epilepsia / Estudos de Associação Genética Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article