Perinatal nicotine exposure delays genital development in mice.
Reprod Toxicol
; 29(3): 378-80, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20080174
ABSTRACT
INTRODUCTION:
Smoking has well-recognized endocrine disrupting effects in humans that have been linked specifically to nicotine in animal models. Nicotine's perinatal effects on genital development in mice, which is interpreted as a measure of endocrine disrupting activity, were evaluated in this report.METHODS:
Pregnant C57B/6J dams were administered 50 microg/ml nicotine in drinking water from gestational day 9 until pups were weaned. Their pups' anogenital distances and weights were measured at birth and at weaning. A subset of the pups was weighed again in adulthood.RESULTS:
Female and male mice had significantly reduced anogenital distance at birth; however, by 34 days of age, differences in anogenital distance were no longer apparent, while body weight, which had been equal at birth and weaning, was significantly reduced in mice exposed to perinatal nicotine.DISCUSSION:
Perinatal nicotine exposure significantly delayed genital development and altered adolescent body weight in this model.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Nicotina
Limite:
Animals
/
Pregnancy
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article