Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIX adjuvanted recombinant antigens.
Vaccine
; 28(14): 2593-7, 2010 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-20096391
ABSTRACT
Deep pulmonary delivery of an influenza ISCOMATRIX vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
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Saponinas
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Adjuvantes Imunológicos
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Colesterol
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Antígenos de Bactérias
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Antígenos Virais
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article