"Weighing in" on synergy: preclinical research on neurohormonal anti-obesity combinations.
Brain Res
; 1350: 86-94, 2010 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-20096672
ABSTRACT
Active weight loss and the maintenance of a weight-reduced state elicit potent counter-regulatory responses in multiple neurochemical pathways rendering monotherapy-based anti-obesity agents relatively ineffective. Herein, we highlight potential strategies for overcoming counter-regulatory responses to states of negative energy balance using combinatorial approaches. We discuss methodological and practical considerations for preclinical modeling of additive/synergistic weight loss combinations that have emerged in our translational research program aimed at identifying naturally occurring neurohormonal synergies. As an example of synergy, pharmacological and mechanistic findings with the combined administration of the beta-cell hormone amylin and the adipokine leptin are reviewed. Finally, we briefly discuss what the future landscape of neurohormonal anti-obesity combinations may hold.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Redução de Peso
/
Leptina
/
Polipeptídeo Amiloide das Ilhotas Pancreáticas
/
Obesidade
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article