The ArcB sensor kinase of Escherichia coli autophosphorylates by an intramolecular reaction.
J Bacteriol
; 192(6): 1735-9, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-20097862
ABSTRACT
The Arc two-component system, comprising the ArcB sensor kinase and the ArcA response regulator, modulates the expression of numerous genes in response to the respiratory conditions of growth. ArcB is a tripartite histidine kinase whose activity is regulated by the oxidation of two cytosol-located redox-active cysteine residues that participate in intermolecular disulfide bond formation. Here we show that ArcB autophosphorylates through an intramolecular reaction which diverges from the usually envisaged intermolecular autophosphorylation of homodimeric histidine kinases.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Regulação Bacteriana da Expressão Gênica
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Regulação Enzimológica da Expressão Gênica
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Proteínas de Escherichia coli
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Escherichia coli
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Proteínas de Membrana
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article