Domino process in silver-catalyzed reactions of N-arylformimidates and active methylene compounds involving cycloisomerization and 1,3-alkenyl shift.
J Am Chem Soc
; 132(6): 1792-3, 2010 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-20104843
ABSTRACT
We have developed an efficient method for the synthesis of 2,3-disubstituted indoles from alkyne iminoethers 1 that employs a domino process involving Ag-catalyzed condensation followed by a tandem Ag-induced cycloisomerization and 1,3-alkenyl shift to Ag-activated carbon. This methodology can be useful in regioselectively constructing 3-alkylated indoles, which are part of the structures of biologically active compounds and important alkaloids.
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1
Base de dados:
MEDLINE
Assunto principal:
Prata
/
Alcenos
/
Imidoésteres
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article