[Expression of T-bet and GATA3 in children with acute idiopathic thrombocytopenic purpura].
Zhongguo Dang Dai Er Ke Za Zhi
; 12(1): 29-31, 2010 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-20113630
ABSTRACT
OBJECTIVE:
To study the expression of transcriptional factors T-bet and GATA3 mRNA and the levels of IFN-gamma and IL-4 in blood in children with acute idiopathic thrombocytopenic purpura (ITP) and investigate the tendency of polarization of Th1/Th2 in children with ITP.METHODS:
Blood T-bet and GATA3 mRNA expression were examined using RT-PCR and plasma IFN-gamma and IL-4 levels were measured using EIASA in children with acute ITP in acute (n=30) and remission stages (n=28). Twenty healthy children served as the controls.RESULTS:
Blood T-bet mRNA expression and IFN-gamma levels in children with ITP in the acute stage were markedly higher than those in the remission stage and controls (p<0.01). In contrast, blood GATA3 mRNA expression and IL-4 levels in children with ITP in the acute stage were significantly lower than those in the remmission stage and controls (p<0.01).CONCLUSIONS:
The high expression of T-bet and IFN-gamma and the low expression of GATA3 and IL-4 indicate the existence of Th1 polarization in children with acute ITP. This might be related to the regulation of T-bet and GATA3.
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Base de dados:
MEDLINE
Assunto principal:
Púrpura Trombocitopênica Idiopática
/
Proteínas com Domínio T
/
Fator de Transcrição GATA3
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article