HIV therapeutic possibilities of gold compounds.
Biometals
; 23(2): 185-96, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-20127392
ABSTRACT
Highly active antiretroviral therapy (HAART) has resulted in decreased mortality and morbidity from the acquired immune deficiency syndrome caused by the human immunodeficiency virus (HIV). Drug resistance and toxicity of HAART has led to the search for novel inhibitors of HIV infection. Gold-based compounds have shown promising activity against a wide range of clinical conditions and microorganism infections including HIV-1. A typical example is auranofin which resulted in an elevated CD4+ T-cell count in an HIV patient being treated for psoriatic arthritis. In addition, reports exist on gold-based inhibitors of reverse transcriptase (RT), protease (PR) and viral entry of host cells. These and other characteristics of gold-based HIV drugs are reviewed here.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Compostos de Ouro
/
Fármacos Anti-HIV
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article