A ketogenic diet does not impair rat behavior or long-term potentiation.
Epilepsia
; 51(8): 1619-23, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20132289
The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically.We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 23 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Gorduras na Dieta
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Córtex Pré-Frontal
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Potenciação de Longa Duração
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article