Your browser doesn't support javascript.
loading
A ketogenic diet does not impair rat behavior or long-term potentiation.
Thio, Liu Lin; Rensing, Nicholas; Maloney, Susan; Wozniak, David F; Xiong, Chengjie; Yamada, Kelvin A.
Afiliação
  • Thio LL; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. thiol@neuro.wustl.edu
Epilepsia ; 51(8): 1619-23, 2010 Aug.
Article em En | MEDLINE | ID: mdl-20132289
The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically.We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2­3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Animal / Gorduras na Dieta / Córtex Pré-Frontal / Potenciação de Longa Duração Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Animal / Gorduras na Dieta / Córtex Pré-Frontal / Potenciação de Longa Duração Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article