Somatic allelic deletion of nm23 in human cancer.
Cancer Res
; 51(9): 2490-3, 1991 May 01.
Article
em En
| MEDLINE
| ID: mdl-2015608
ABSTRACT
Tumor progression to the metastatic phenotype is accompanied in certain cell types by reduced expression of the nm23 gene. We have localized human nm23-H1 to chromosome 17 by somatic cell hybrid analysis. Regional localization in the CEPH database and in situ hybridization is reported. Somatic allelic deletion of nm23-H1 was observed in human breast, renal, colorectal, and lung carcinoma DNA samples, as compared to DNA from matched normal tissues. A homozygous deletion of nm23-H1 was observed in a lymph node metastasis of a colorectal carcinoma, indicating that nm23-H1 can be recessively inactivated. The data identify nm23-H1 as a novel, independent locus for allelic deletion in human cancer, a characteristic shared with previously described suppressor genes.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Cromossomos Humanos Par 17
/
Proteínas
/
Deleção Cromossômica
/
Núcleosídeo-Difosfato Quinase
/
Proteínas Monoméricas de Ligação ao GTP
/
Alelos
/
Proteínas de Neoplasias
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article