New multispectral MRI data fusion technique for white matter lesion segmentation: method and comparison with thresholding in FLAIR images.
Eur Radiol
; 20(7): 1684-91, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20157814
ABSTRACT
OBJECTIVE:
Brain tissue segmentation by conventional threshold-based techniques may have limited accuracy and repeatability in older subjects. We present a new multispectral magnetic resonance (MR) image analysis approach for segmenting normal and abnormal brain tissue, including white matter lesions (WMLs).METHODS:
We modulated two 1.5T MR sequences in the red/green colour space and calculated the tissue volumes using minimum variance quantisation. We tested it on 14 subjects, mean age 73.3 +/- 10 years, representing the full range of WMLs and atrophy. We compared the results of WML segmentation with those using FLAIR-derived thresholds, examined the effect of sampling location, WML amount and field inhomogeneities, and tested observer reliability and accuracy.RESULTS:
FLAIR-derived thresholds were significantly affected by the location used to derive the threshold (P = 0.0004) and by WML volume (P = 0.0003), and had higher intra-rater variability than the multispectral technique (mean difference +/- SD 759 +/- 733 versus 69 +/- 326 voxels respectively). The multispectral technique misclassified 16 times fewer WMLs.CONCLUSION:
Initial testing suggests that the multispectral technique is highly reproducible and accurate with the potential to be applied to routinely collected clinical MRI data.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Neoplasias Encefálicas
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article