Peroxisome proliferator-activated receptor (PPAR): balance for survival in parasitic infections.
J Biomed Biotechnol
; 2010: 828951, 2010.
Article
em En
| MEDLINE
| ID: mdl-20169106
ABSTRACT
Parasitic infections induce a magnitude of host responses. At the opposite ends of the spectrum are those that ensure the host's needs to eliminate the invaders and to minimize damage to its own tissues. This review analyzes how parasites would manipulate immunity by activating the immunosuppressive nuclear factor, peroxisome proliferator-activated receptors (PPARs) with type 2 cytokines and free fatty acids from arachidonic acid metabolism. PPARs limit the action of type 1 immunity, in which classically activated macrophages act through the production of proinflammatory signals, to spare the parasites. They also favor the development of alternately activated macrophages which control inflammation so the host would not be destroyed. Possibly, the nuclear factors hold a pivotal role in the establishment of chronic infection by delicately balancing the pro- and anti-inflammatory signaling mechanisms and their ligands may be used as combination therapeutics to limit host pathology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Parasitárias
/
Receptores Ativados por Proliferador de Peroxissomo
/
Evasão da Resposta Imune
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article