Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.
Eukaryot Cell
; 9(4): 667-70, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-20173034
ABSTRACT
Toxoplasma gondii CDPK1 (TgCDPK1) was found to be the target of the toxoplasmocidal compound 1NM-PP1. When TgCDPK1 was mutated at position 128 from glycine to methionine, resistance was gained. Inhibition of gliding motility without inhibition of micronemal secretion by 1NM-PP1 suggests a function for TgCDPK1 in gliding motility.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Pirazóis
/
Pirimidinas
/
Toxoplasma
/
Proteínas de Protozoários
/
Movimento Celular
/
Inibidores de Proteínas Quinases
Limite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article