A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody.
Immunol Cell Biol
; 88(5): 605-11, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20177411
ABSTRACT
A conserved 15 amino-acid residue sequence of the ectodomain of the M2 protein of influenza A virus (M2e) induces a strong antibody (Ab) response when incorporated into a synthetic lipopeptide vaccine candidate containing a T-helper epitope from influenza A hemagglutinin and the dendritic cell-targeting lipid moiety S-[2,3-bis(palmitoyloxy)propyl]cysteine (Pam2Cys). Abs elicited by the truncated M2e sequence were specific for the M2 protein of influenza A virus and were also capable of binding to cells that were infected with influenza A viruses of different subtypes. The Ab titres against the lipopeptide were similar in magnitude to those elicited by the full-length (23 residue) M2e peptide when administered in Freund's adjuvant. Abs to the truncated M2e sequence were also able to significantly reduce the viral load in airways of BALB/c mice after challenge with live influenza virus.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
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Vacinas contra Influenza
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Proteínas da Matriz Viral
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Lipopeptídeos
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Anticorpos Antivirais
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Antígenos Virais
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article