Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides.
Nucleosides Nucleotides Nucleic Acids
; 28(5): 713-23, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-20183611
ABSTRACT
A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Pirimidinas
/
Ribonucleosídeos
/
Hepacivirus
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article