Biological therapies for cardiac arrhythmias: can genes and cells replace drugs and devices?
Circ Res
; 106(4): 674-85, 2010 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-20203316
ABSTRACT
Cardiac rhythm disorders reflect failures of impulse generation and/or conduction. With the exception of ablation methods that yield selective endocardial destruction, present therapies are nonspecific and/or palliative. Progress in understanding the underlying biology opens up prospects for new alternatives. This article reviews the present state of the art in gene- and cell-based therapies to correct cardiac rhythm disturbances. We begin with the rationale for such approaches, briefly discuss efforts to address aspects of tachyarrhythmia, and review advances in creating a biological pacemaker to cure bradyarrhythmia. Insights gained bring the field closer to a paradigm shift away from devices and drugs, and toward biologics, in the treatment of rhythm disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
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Relógios Biológicos
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Terapia Genética
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Transplante de Células
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Sistema de Condução Cardíaco
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Frequência Cardíaca
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article