Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
PLoS One
; 5(3): e9468, 2010 Mar 02.
Article
em En
| MEDLINE
| ID: mdl-20209148
ABSTRACT
BACKGROUND:
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. METHODOLOGY/PRINCIPALFINDINGS:
Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced body weight, partial resistance to age- or diet-induced obesity, and overall improved metabolic status. Alteration in the liver gene expression profile, in behavior and metabolism point to a calorie restriction-like phenotype in Eps8 knockout mice. Additionally, and consistent with a calorie restricted metabolism, Eps8 knockout mice show increased lifespan. The metabolic alterations in Eps8 knockout mice correlated with a significant reduction in intestinal fat absorption presumably caused by a 25% reduction in intestinal microvilli length. CONCLUSIONS/SIGNIFICANCE:
Our findings implicate actin dynamics as a novel variable in the determination of longevity. Additionally, our observations suggest that subtle differences in energy balance can, over time, significantly affect bodyweight and metabolic status in mice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Actinas
/
Proteínas do Citoesqueleto
/
Proteínas Adaptadoras de Transdução de Sinal
/
Mucosa Intestinal
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article