Pilot study of serum inhibin B as a potential marker of testosterone doping in weight lifting men.
Clin J Sport Med
; 20(2): 117-9, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-20215894
ABSTRACT
OBJECTIVE:
The aim of this study was to explore effectors of the pituitary-testicular axis suitable as potential biochemical markers to screen for testosterone doping.DESIGN:
Pilot study with male bodybuilding athletes with a self-reported history of testosterone doping (repeated intramuscular administration of testosterone preparations, last injection 8 weeks or less ago) compared with an equal sized control group matched for sex, age, and body mass index.SETTING:
Endocrine outpatients.PARTICIPANTS:
Fifteen healthy young men of white background.INTERVENTIONS:
None. MAIN OUTCOMEMEASURES:
Inhibin B, testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH).RESULTS:
Although the levels of testosterone, LH, and FSH did not differ between the 2 groups, the serum concentrations of inhibin B in individuals with a history of testosterone doping were exclusively at or below the lower limit of the normal range for adult men (100-400 pg/mL). Inhibin B was significantly lower in those men who used testosterone for weight lifting (76.1 +/- 36.3 ng/L [mean +/- SD]) than in controls (182.1 +/- 35.4 ng/L).CONCLUSION:
A low concentration of serum inhibin B may reflect the application of exogenous testosterone and appears to be a potential marker associated with anabolic androgenic steroid doping.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Levantamento de Peso
/
Detecção do Abuso de Substâncias
/
Dopagem Esportivo
/
Androgênios
/
Inibinas
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article