A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome.
J Eur Acad Dermatol Venereol
; 24(8): 967-9, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20236208
ABSTRACT
BACKGROUND:
Papillon-Lefevre syndrome (PLS; OMlM 245000) is an autosomal recessive disease caused by mutations in cathepsin C (CTSC) gene and is characterized by palmoplantar keratoderma, psoriasiform lesion over the extensor surfaces and gingivitis followed by loss of teeth. CTSC gene is expressed in several tissues including the skin and cells of the immune system. In the skin, CTSC plays a role in differentiation and desquamation, whereas in the immune system, it activates serine proteases.OBJECTIVES:
We analysed the molecular basis of PLS in a Pakistani family.METHODS:
Genomic DNA was isolated from the sample according to standard techniques. All exons of the CTSC gene with adjacent sequences of exon-intron borders were amplified by PCR and directly sequenced.RESULTS:
We identified a novel deletion mutation designated c.2ldelG (Leu7PhefsX57) in exon 1 of the CTSC gene, which probably results in the absence of CTSC protein.CONCLUSION:
Our data further expand the spectrum of mutations in the CTSC gene underlying PLS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Papillon-Lefevre
/
Deleção de Sequência
/
Catepsina C
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article