DNA analysis of HLA-DR4B1 subtypes in multiple sclerosis by specific oligonucleotide probes.
J Neuroimmunol
; 32(3): 279-83, 1991 Jun.
Article
em En
| MEDLINE
| ID: mdl-2033119
ABSTRACT
Conversely to the well-established association of DR2/Dw2 with multiple sclerosis (MS) susceptibility in Caucasoids, several studies have found an association of DR4 in populations from Mediterranean origin. We have studied the distribution of the different DR4B1 subtypes in Spanish MS patients. Oligonucleotide probes were selected in order to type samples amplified by polymerase chain reaction (PCR) from Spanish DR4+ MS patients (25) and controls (28). No DR4B1 subtypes were found to be increased in MS. MS susceptibility linked to DR4 may be due to the presence of shared functional epitopes common to the different HLA-DR4B1 subtypes.
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Base de dados:
MEDLINE
Assunto principal:
DNA
/
Sondas de Oligonucleotídeos
/
Antígenos HLA-DR
/
Esclerose Múltipla
Limite:
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article