Pharmacological modulators of the circadian clock as potential therapeutic drugs.
Mutat Res
; 680(1-2): 109-15, 2009.
Article
em En
| MEDLINE
| ID: mdl-20336820
ABSTRACT
Circadian clocks are molecular time-keeping systems that underlie daily fluctuations in multiple physiological and biochemical processes. It is well recognized now that dysfunctions of the circadian system (both genetically and environmentally induced) are associated with the development of various pathological conditions. Here we describe the application of high throughput screening approach designed to search for small molecules capable of pharmacological modulation of the molecular clock. We provide evidence for the feasibility and value of this approach for both scientific and therapeutic purposes.
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Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Xenobióticos
/
Ritmo Circadiano
/
Tratamento Farmacológico
/
Fatores Imunológicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article