Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies.
Bioorg Med Chem
; 18(9): 3320-34, 2010 May 01.
Article
em En
| MEDLINE
| ID: mdl-20346684
ABSTRACT
Novel alpha-mannosidase inhibitors of the type (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-arylethyl]amino}methyl)pyrrolidine-3,4-diol have been prepared and assayed for their anticancer activities. Compound 30 with the aryl group=4-trifluoromethylbiphenyl inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Teprotida
/
Neoplasias Hematológicas
/
Alfa-Manosidase
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article