Minireview: Estrogen receptor-beta: mechanistic insights from recent studies.
Mol Endocrinol
; 24(9): 1703-14, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20363876
ABSTRACT
The discovery of estrogen receptor-beta (ERbeta) in 1996 stimulated great interest in the physiological roles and molecular mechanisms of ERbeta action. We now know that ERbeta plays a major role in mediating estrogen action in several tissues and organ systems, including the ovary, cardiovascular system, brain, and the immune system, and that ERbeta and ERalpha generally play distinct physiological roles in the body. Although significant progress has been made toward understanding the molecular mechanisms of ERbeta action, particularly in vitro, there remains a large gap in our understanding of the mechanisms by which ERbeta elicits its biological functions in a true physiological context.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptor beta de Estrogênio
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article