Heat shock memory in preimplantation mouse embryos.
Fertil Steril
; 93(8): 2760-3, 2010 May 15.
Article
em En
| MEDLINE
| ID: mdl-20378108
ABSTRACT
To investigate the consequences of possible physiologic stress to embryos caused by in vitro fertilization procedures, we used heat shock response in preimplantation mouse embryos as a model. A heat shock "memory" was discovered that renders cleavage-stage embryos more responsive at the transcriptional level to secondary perturbation with very low doses of heat, even several cell cycles after the initial stress has occurred.
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Base de dados:
MEDLINE
Assunto principal:
Blastocisto
/
Resposta ao Choque Térmico
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article