Electromechanical wavebreak in a model of the human left ventricle.
Am J Physiol Heart Circ Physiol
; 299(1): H134-43, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20400690
ABSTRACT
In the present report, we introduce an integrative three-dimensional electromechanical model of the left ventricle of the human heart. Electrical activity is represented by the ionic TP06 model for human cardiac cells, and mechanical activity is represented by the Niederer-Hunter-Smith active contractile tension model and the exponential Guccione passive elasticity model. These models were embedded into an anatomic model of the left ventricle that contains a detailed description of cardiac geometry and the fiber orientation field. We demonstrated that fiber shortening and wall thickening during normal excitation were qualitatively similar to experimental recordings. We used this model to study the effect of mechanoelectrical feedback via stretch-activated channels on the stability of reentrant wave excitation. We found that mechanoelectrical feedback can induce the deterioration of an otherwise stable spiral wave into turbulent wave patterns similar to that of ventricular fibrillation. We identified the mechanisms of this transition and studied the three-dimensional organization of this mechanically induced ventricular fibrillation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Ventricular
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Função Ventricular Esquerda
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Acoplamento Excitação-Contração
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Sistema de Condução Cardíaco
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Ventrículos do Coração
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Modelos Anatômicos
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Modelos Cardiovasculares
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Contração Miocárdica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article