Sequence-specific recognition of methylated DNA by human zinc-finger proteins.
Nucleic Acids Res
; 38(15): 5015-22, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20403812
ABSTRACT
DNA methylation is an essential epigenetic mark. Three classes of mammalian proteins recognize methylated DNA MBD proteins, SRA proteins and the zinc-finger proteins Kaiso, ZBTB4 and ZBTB38. The last three proteins can bind either methylated DNA or unmethylated consensus sequences; how this is achieved is largely unclear. Here, we report that the human zinc-finger proteins Kaiso, ZBTB4 and ZBTB38 can bind methylated DNA in a sequence-specific manner, and that they may use a mode of binding common to other zinc-finger proteins. This suggests that many other sequence-specific methyl binding proteins may exist.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Metilação de DNA
/
Proteínas de Ligação a DNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article