Pre-clinical safety evaluation of pyrrolidine dithiocarbamate.
Basic Clin Pharmacol Toxicol
; 107(3): 758-67, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20406205
ABSTRACT
Pyrrolidine dithiocarbamate (PDTC) was examined for its potential in the intranasal treatment of human rhinovirus infections. Prior to clinical testing, a comprehensive non-clinical programme was performed to evaluate the general toxicity of PDTC. The animal experiments included investigations in rodents with study durations ranging from single dose to repeated dosing over a period of 28 days. The routes of administration were intranasal, inhalative, oral and intravenous for single-dose toxicity and pharmacokinetic studies, and intranasal for repeated dose studies. Blood and tissue samples were obtained from PDTC-treated rats to analyse pharmacokinetics and tissue distribution. Accumulation of selected metals due to PDTC treatment was examined in liver, brain, nerves and fat tissues.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Pirrolidinas
/
Tiocarbamatos
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article