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Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers.
Yang, Yang; Song, Weixing; Wang, Anhe; Zhu, Pengli; Fei, Jinbo; Li, Junbai.
Afiliação
  • Yang Y; National Center for Nanoscience and Technology, No. 11, Bei Yi Tiao, Zhong guan cun, Beijing, 100190, China.
Phys Chem Chem Phys ; 12(17): 4418-22, 2010 May 07.
Article em En | MEDLINE | ID: mdl-20407714
This paper presents a strategy for the biofunctionalization of novel photosensitizer carriers, mesoporous silica nanoparticles (MSNs). After being calcined and absorbed with photosensitizers (hypocrellin B, HB), MSNs can be coated with a lipid layer. Transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM) results proved that HB molecules can be loaded into MSN porous and lipid can coated on the surface of the nanoparticles. When co-cultured with cancer cells (MCF-7), MSNs can transport HB molecules into cells and present low cytotoxicity. With the introduction of a lipid layer, the efficiency of MSN uptake by cells can be improved. These intracellular HB-loaded MSN materials also present cytotoxicity to MCF-7 cells after light irradiation which indicates the materials can be used as good photosensitizer carriers in photodynamic therapy.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Perileno / Quinonas / Portadores de Fármacos / Fármacos Fotossensibilizantes / Dióxido de Silício / Nanopartículas Limite: Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Perileno / Quinonas / Portadores de Fármacos / Fármacos Fotossensibilizantes / Dióxido de Silício / Nanopartículas Limite: Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article