Role of hematopoietic cells in the maintenance of chronic human torquetenovirus plasma viremia.
J Virol
; 84(13): 6891-3, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20410268
ABSTRACT
Many aspects of the life cycle of torquetenoviruses (TTVs) are essentially unexplored. In particular, it is still a matter of speculation which cell type(s) replicates the viruses and maintains the generally high viral loads found in the blood of infected hosts. In this study, we sequentially measured the TTV loads in the plasma of four TTV-positive leukemia patients who were strongly myelosuppressed and then transplanted with haploidentical hematopoietic stem cells. The findings provide clear quantitative evidence for an extremely important role of hematopoietic cells in the maintenance of TTV viremia.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Plasma
/
Viremia
/
DNA Viral
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Células-Tronco Hematopoéticas
/
Vírus de DNA
Limite:
Adult
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article