Invariant Valpha14 natural killer T cell activation by edible mushroom acidic glycosphingolipids.
Biol Pharm Bull
; 33(4): 580-4, 2010.
Article
em En
| MEDLINE
| ID: mdl-20410589
ABSTRACT
Invariant natural killer T (iNKT) cells regulate multi-immune response through Th1/Th2 cytokine release triggered by the recognition of CD1d-restricted glycosphingolipid antigens. Here we report that acidic glycosphingolipids (AGLs) of mushroom (Hypsizigus marmoreus and Pleurotus eryngii) presented by murine CD1d-transfected rat basophilic leukocytes induced interleukin-2 (IL-2) release from iNKT hybridoma cells. AGL-1, one of the AGLs, containing mannose at the non-reducing ends, induced CD1d-dependent IL-2 release. Al-though alpha-galactosylceramide (alpha-GalCer) presented by CD11c-positive cells induced both interferon-gamma (IFN-gamma) and IL-4 release, all of AGLs presented by CD11c-positive cells and AGL-1 presented by B cells induced IL-4 release from iNKT hybridoma cells. A single intravenous injection of AGLs into B6 mice induced only a little elevation of IL-4 in serum but repeated intravenous injection of AGLs induced prolonged retention of IL-4 in serum; therefore, these results suggested that edible mushroom AGLs might contribute to the retention of immunohomeostasis through the minimum induction of iNKT cell activation in vivo.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Ativação Linfocitária
/
Receptores de Antígenos de Linfócitos T
/
Adjuvantes Imunológicos
/
Glicoesfingolipídeos Acídicos
/
Agaricales
/
Células T Matadoras Naturais
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article