Polymorphisms in DNA damage response genes and head and neck cancer risk.
Biomarkers
; 15(5): 379-99, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20429839
ABSTRACT
BACKGROUND:
Polymorphisms in DNA repair genes have been reported contributing factors in head and neck cancer risk but studies have shown conflicting results.OBJECTIVE:
To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk.METHOD:
A meta-analysis including 30 case-control studies was performed.RESULTS:
Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer.CONCLUSION:
Assessments of the effects of smoking, alcohol, human papillomavirus and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Proteínas de Ligação a DNA
/
Neoplasias de Cabeça e Pescoço
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article