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[Natural history study of postoperative residual non-functioning pituitary adenomas].
Wu, Zhe-bao; Chen, Yong; Lü, Qing-ping; Wang, Cheng-de; Su, Zhi-Peng; Wu, Jin-sen; Zheng, Wei-ming; Zhuge, Qi-chuan.
Afiliação
  • Wu ZB; Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China. zhebaowu@yahoo.com.cn
Zhonghua Yi Xue Za Zhi ; 90(9): 597-600, 2010 Mar 09.
Article em Zh | MEDLINE | ID: mdl-20450781
ABSTRACT

OBJECTIVE:

To observe the postoperative residual non-functioning pituitary adenomas (PR-NFPAs) without postoperative radiotherapy and to analyze the natural history of PR-NFPAs' growth in order to provide a basis for selecting appropriate strategies of clinical treatment.

METHODS:

We evaluated the natural history of 20 patients with PR-NFPAs who did not receive postoperative radiotherapy and drug therapy. Through MRI images, the residual tumor volumes of those patients were serially measured. We further calculated the monthly growth rate and the tumor volume doubling time (TVDT) and analyzed the correlations between the patient age, gender, volume of residual tumor, cavernous sinus (CS) invasion and TVDT.

RESULTS:

All patients received observation alone. Among which, 17 adenomas increased in volume and 3 remained unchanged during a follow-up period of 7 months to 17 years (mean 3.90 yr). The mean patient age was 41.8 years. As to 17 patients with tumor regrowth, the tumor volume at the beginning of MRI observation period was 4.73 cm(3) and tumor volume at the last MRI observation was 16.98 cm(3). During the mean 4-year follow-up period, the average monthly growth rate of PR-NFPAs was 7.87% and the mean TVDT was 724 days. Such factors as patient age, gender, volume of residual tumor and CS invasion did not affect the TVDT of PR-NFPAs.

CONCLUSION:

The tumor growth rate of PR-NFPAs is not significantly correlated with the patient gender, age, volume of residual tumor and CS invasion. In conjunctions with the volume of PR-NFPAs and the distance between residual adenoma and optic chiasm, we should take the TVDT into consideration and determine the appropriate and safe follow-up period.
Assuntos
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Base de dados: MEDLINE Assunto principal: Neoplasias Hipofisárias / Adenoma / Neoplasia Residual Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: Zh Ano de publicação: 2010 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Neoplasias Hipofisárias / Adenoma / Neoplasia Residual Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: Zh Ano de publicação: 2010 Tipo de documento: Article