Effects of natalizumab on circulating B cells, T regulatory cells and natural killer cells.
Eur Neurol
; 63(5): 311-7, 2010.
Article
em En
| MEDLINE
| ID: mdl-20453514
ABSTRACT
BACKGROUND:
Natalizumab is a humanized monoclonal antibody directed against very late activation antigen 4 (VLA-4) and has a potent effect on disease activity in multiple sclerosis. Blockade of VLA-4 with natalizumab may not only interfere with autoimmunological mechanisms but also with central nervous system immune surveillance.METHODS:
Longitudinal ex vivo and in vitro study to determine the effect of natalizumab on the frequency of distinct immune cells and on the frequency and suppressive function of natural CD4+CD25+ regulatory T cells (Tregs).RESULTS:
Natalizumab binding to VLA-4 was more marked for B cells than for T cells (49% reduction in VLA-4-expressing B cells compared to 24.5% reduction of T cells). There was an increase in circulating B cells over T cells (2.6 vs. 1.5 fold, p < 0.001). Natural killer cells increased 1.5-fold (p = 0.01). Natalizumab led to a relative decrease in CD4+CD25+ Tregs from 18.9 to 14.1% (p = 0.04). The impaired suppressive capacity of Tregs was not restored.CONCLUSION:
Natalizumab reduces VLA-4 expression on all investigated immune cells, but changes were most marked for B cells. Further differential effects on immune cells may be relevant to opportunistic central nervous system infections during treatment with natalizumab.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Células Matadoras Naturais
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Linfócitos T Reguladores
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Integrina alfa4beta1
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Fatores Imunológicos
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Anticorpos Monoclonais
Tipo de estudo:
Observational_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article