Biomimetic oxidation of piperine and piplartine catalyzed by iron(III) and manganese(III) porphyrins.
Biol Pharm Bull
; 33(5): 912-6, 2010.
Article
em En
| MEDLINE
| ID: mdl-20460777
ABSTRACT
Synthetic metalloporphyrins, in the presence of monooxygen donors, are known to mimetize various reactions of cytochrome P450 enzymes systems in the oxidation of drugs and natural products. The oxidation of piperine and piplartine by iodosylbenzene using iron(III) and manganese(III) porphyrins yielded mono- and dihydroxylated products, respectively. Piplartine showed to be a more reactive substrate towards the catalysts tested. The structures of the oxidation products were proposed based on electrospray ionization tandem mass spectrometry.
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Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Piperidonas
/
Porfirinas
/
Compostos Férricos
/
Biomimética
/
Alcaloides
/
Benzodioxóis
/
Alcamidas Poli-Insaturadas
/
Ferro
/
Manganês
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article