Combined InCl3- and amine-catalyzed intramolecular addition of alpha-disubstituted aldehydes onto unactivated alkynes.
Org Lett
; 12(11): 2582-5, 2010 Jun 04.
Article
em En
| MEDLINE
| ID: mdl-20462188
ABSTRACT
The combination of enamine-type catalysis to the indium-catalyzed activation of alkynes allows the efficient preparation of functionalized cyclopentanes bearing a quaternary stereogenic center. A broad range of formylalkynyl derivatives has been prepared. The InCl(3)/(Cy)(i-Pr)NH system efficiently promotes the carbocyclization reaction of alpha-disubstituted aldehydes in good to excellent yields.
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MEDLINE
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En
Ano de publicação:
2010
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Article