Kidney disease associated with plasma cell dyscrasias.
Blood
; 116(9): 1397-404, 2010 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-20462963
ABSTRACT
Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paraproteinemias
/
Nefropatias
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article