Analysis of the complete genome sequences of human rhinovirus.
J Allergy Clin Immunol
; 125(6): 1190-9; quiz 1200-1, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20471068
ABSTRACT
Human rhinovirus (HRV) infection is the cause of about one half of asthma and chronic obstructive pulmonary disease exacerbations. With more than 100 serotypes in the HRV reference set, an effort was undertaken to sequence their complete genomes so as to understand the diversity, structural variation, and evolution of the virus. Analysis revealed conserved motifs, hypervariable regions, a potential fourth HRV species, within-serotype variation in field isolates, a nonscanning internal ribosome entry site, and evidence for HRV recombination. Techniques have now been developed using next-generation sequencing to generate complete genomes from patient isolates with high throughput, deep coverage, and low costs. Thus relationships can now be sought between obstructive lung phenotypes and variation in HRV genomes in infected patients and potential novel therapeutic strategies developed based on HRV sequence.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rhinovirus
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DNA Viral
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Genoma Viral
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Infecções por Picornaviridae
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Doença Pulmonar Obstrutiva Crônica
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article